The Optimal Dosage of Methotrexate for Graft-Versus-Host Disease Prophylaxis in Umbilical Cord Blood Transplantation
نویسندگان
چکیده
منابع مشابه
Acute graft-versus-host disease after unrelated donor umbilical cord blood transplantation: analysis of risk factors.
Acute graft-versus-host disease (GVHD) occurs less frequently after umbilical cord blood transplantation (UCBT). More recent investigations include the use of 2 partially human leukocyte antigen (HLA)-matched UCB units, or double UCB graft, to meet the minimum cell-dose requirement. The purpose of this analysis was to assess the relative risk of acute GVHD in 265 consecutive patients receiving ...
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The use of peripheral blood progenitor cells (PBPCs) for allogeneic transplantation (allo-PBPCT) is raising considerable interest.' One of the main potential advantages of allo-PBPCT is a rapid neutrophil and platelet engraftment.2 In a recent issue of Blood three report^^.^ describe the clinical results of using PBPCs for allografting. Whereas two of find that allo-PBPCT is associated to a ve...
متن کاملCLINICAL TRIALS AND OBSERVATIONS Acute graft-versus-host disease after unrelated donor umbilical cord blood transplantation: analysis of risk factors
Acute graft-versus-host disease (GVHD) occurs less frequently after umbilical cord blood transplantation (UCBT). More recent investigations include the use of 2 partially human leukocyte antigen (HLA)–matched UCB units, or double UCB graft, to meet the minimum cell-dose requirement. The purpose of this analysis was to assess the relative risk of acute GVHD in 265 consecutive patients receiving ...
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Calcineurin inhibition for graft-versus-host disease (GvHD) prophylaxis was introduced into clinical practice of bone marrow transplantation about 35 years ago. Through the early work of Storb, Deeg and Ringden it became clear that calcineurin inhibition with cyclosporine A as a single agent was more effective than methotrexate alone and that the two drugs acted synergistically (see Table 1 for...
متن کاملRelationship between Molecular Chimerism and Graft Versus Host Disease after Allogenic Hematopoietic Stem Cell Transplantation
Background: Bone marrow transplantation (BMT) is considered as a curative therapy for a broad range of diseases. However, complications such as relapse and graft versus host disease (GVHD) may be observed following BMT. Chimerism analysis serves as a reliable indicator of transplant outcome. Complete chimerism refers to the complete replacement of hematopoietic system by donor cells, while mixe...
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ژورنال
عنوان ژورنال: Biology of Blood and Marrow Transplantation
سال: 2019
ISSN: 1083-8791
DOI: 10.1016/j.bbmt.2018.12.269